PDRA (Vascular electrophysiology and Small Vessel Diseases of the Brain)

We are seeking a motivated and collaborative individual to join our team as a postdoctoral research associate. This role offers an exciting opportunity to contribute to the newly established NaVigate programme to develop treatment options for Alzheimer’s Disease and other small vessel diseases of the brain. The position will be initially available for 3 years, with the possibility of extending up to 5 years. The research will be carried out in the View email address on jobs.manchester.ac.uk group ( microvascularmanchester.com ) under the guidance of Professor Adam Greenstein and Dr Harry Pritchard. The post will be based within the Division of Cardiovascular Sciences at the University of Manchester and the Geoffrey Jefferson Brain Research Centre.

You will be responsible for:

• Leading research into the mechanisms underlying hypertension-related and amyloid-induced changes to cerebral small artery vascular smooth muscle cell and endothelial cell ion channel activity

• To prepare material for publications and conference presentations.
• To write reports for submission to research sponsors and partake in relevant meetings.
• To be an active team-member and set positive examples by showing a commitment to achieving results, encouraging and supporting junior members of the team and raising suggestions for continuous improvement.

We welcome candidates who bring diverse perspectives, experiences, and approaches to their work.

About You

We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate:

Essential Criteria:

• Have, or be about to obtain, a PhD (or equivalent) in biophysics and membrane biology (or similar)
• Extensive and up-to-date understanding of ion channel biophysics.
• Hands-on experience in native (freshly isolated) single cell patch clamp electrophysiology with competence in hardware and software assembly, maintenance and data analysis
• Experience with animal models
• Strong journal publication record.

Desirable Criteria:

• Experience and understanding of cardiovascular physiology, preferably in the field of small artery biology.
• Cardiovascular, particularly microvascular, patch clamp expertise.
• Flexible approach to dealing with research problems as they arise
• Willingness to learn and develop
• Ability to assess and organise resources

We value transferable skills and real-world experience as much as formal qualifications.

Our benefits include:
• Generous employer contribution pension
• 29 days annual leave plus bank holidays, along with Christmas closure
• Ride to work and EV car scheme available

For more information, please see University of Manchester Benefits . You can also find information on our Flexible and Hybrid working here .

We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy .

Enquiries about the role, shortlisting and interviews

Name: Professor Adam Greenstein

Email Address: View email address on jobs.manchester.ac.uk

General enquiries and administrative support

View email address on jobs.manchester.ac.uk

Technical and job portal support

This role is not eligible for Skilled Worker visa sponsorship. Applicants must demonstrate the right to work in the UK.

Applications close at midnight on the closing date.

Further particulars (with person specification) linked below.