Principal Safety Scientist

Job Purpose
Provides medical/scientific knowledge in the safety evaluation and risk management of GSK products in clinical development and/or the post-marketing setting.

Ensures scientifically sound review and interpretation of data and management of safety issues and escalates safety issues identified through the safety review process to senior management and safety governance as appropriate. Makes recommendations for the further characterization, management, and communication of safety risks.

Focus on efficiency and effectiveness to meet the needs of our Patients and HCPs. Supporting the pharmacovigilance and benefit-risk management of the assigned portfolio of GSK global assets to ensure Patient Safety globally.

If appointed as a manager (i.e., Team/Group Leader) is responsible for leadership of a team of individual contributors. Line Management (including functional matrix reports) leadership competencies include resource and team management, coaching, influencing others, collaborative working, decision making, change management, partnership, and relations management.

In this role you will...
Scientific/Medical Knowledge & PV Expertise

• Leads signal detection and evaluation activities for assigned products.
• Produces clear, accurate, and fit-for-purpose safety evaluations in response to internal and regulatory requests.
• Contributes to Risk Management Plans (RMPs), risk assessments, and safety documentation in collaboration with senior colleagues.
• Authors and reviews global periodic safety reports, aggregate reports, protocols, and other regulatory documents within agreed timelines.
• Participates in process improvement initiatives and ensures timely completion of audit and inspection follow-up activities.
• Utilizes multiple data sources to investigate safety issues, propose solutions, and support decision-making in consultation with SERM physicians.
• Effectively prioritizes workload, manages competing deadlines, and consistently delivers high-quality outputs with minimal supervision.

2. Cross-Functional Matrix Leadership

• Builds strong collaborative relationships across functions to address product safety matters.
• Supports Safety Review Teams (SRTs) and governance activities in both development and post-marketing settings, helping to identify, evaluate, and mitigate safety risks.
• Contributes to the implementation of risk minimization strategies in clinical protocols and product labeling.

3. Communication & Influencing

• Demonstrates strong verbal, written, and medical/scientific communication skills, producing high-quality evaluations and reports.
• Supports and communicates safety risk positions clearly to internal and external stakeholders.

Why You?
Basic Qualification
We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• Degree in a health or life sciences discipline or healthcare professional qualification (for example, PharmD, PhD, RN, RPh, BSc) or equivalent experience.
• Experience in pharmacovigilance, safety evaluation, clinical safety or a related role in the pharmaceutical or biotech industry.
• Practical knowledge of safety evaluation methods, signal detection principles and adverse event reporting.
• Experience with clinical development and post-marketing safety activities.
• Good clinical and scientific literacy, including understanding of medical terminology and study design.

Preferred Qualification
If you have the following characteristics, it would be a plus:

• Advanced medical or scientific degree (for example, PhD, MSc) or clinical training.
• Experience authoring or contributing to regulatory safety documents and risk management plans.
• Experience working across global teams and multi-country safety requirements.
• Familiarity with pharmacovigilance regulations and guidance in global regions.
• Experience with safety databases and safety signal detection tools.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at View email address on meeveem.com where you can also request a call.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the Link where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at