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Computational Chemist

£20.1 - £23.4 per hourEstimated
Full-time
Responsibilities
  • Own the end-to-end execution and monitoring of QEMI virtual screening and hit expansion campaigns across all active pre-programs
  • Select and prepare appropriate protein structures based on target biology, binding site context, and program objectives
  • Run and interpret screenability assessments, configure workflows, and coordinate screening execution with compute and engineering teams
  • Apply compound filtering and selection workflows, ensuring compounds meet registration, traceability, and screenability standards
  • Active contributor to pre-programs prioritization strategy by doing retrospectives of the screens, and identifying areas of improvement
  • Troubleshoot underperforming runs and identify structural, methodological, or operational improvements to increase hit quality and workflow reliability
  • Partner with engineering and platform teams to standardize, document, and progressively automate the run process as the platform evolves
  • Maintain robust operational documentation and backup processes to ensure continuity and resilience across team changes and scaling needs
Qualifications
  • Strong background in computational chemistry, cheminformatics, or computer-aided drug design (CADD)
  • Experience with structure-based virtual screening workflows, docking, scoring, and hit triage
  • Ability to independently assess protein structure quality and make scientific decisions on structure selection and screening strategy
  • Strong working knowledge of Python and scientific scripting workflows, including troubleshooting and modifying existing pipelines
  • Comfortable working in Linux environments and with command-line tools, configuration files, and automated workflows
  • Familiarity with chemical data handling and compound registration workflows, including SMILES and RDKit
  • Minimum 6 years of relevant experience in computational chemistry or related scientific fields
Nice‑to‑Have
  • Experience supporting early discovery or preclinical drug discovery programs in biotech or pharma
  • Familiarity with protein folding methods and structure prediction workflows
  • Understanding of medicinal chemistry concepts such as drug-likeness, developability, and ADMET
  • Experience contributing operational insights into platform or product improvement roadmaps
  • Prior experience scaling or standardising scientific workflows across multiple programs
Vacancy posted a month ago
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