IT Systems Analyst

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development. The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radioconjugates (BRCs) and imaging agents;; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle® technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit bicycletherapeutics.com

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous . We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission . You can’t change the world if you don’t have determination.
• We are One Team . We only succeed when we work together.

WORKING CLASSIFICATION : Onsite

This is a fully onsite position based at our Cambridge, UK facilities. Given the collaborative and operational nature of this role, daily onsite presence is required to work closely with our teams, access our cutting-edge resources, and drive our science and operations forward.

Job Description

As our Corporate IT team across the UK & US has evolved, we have created an exciting opportunity for an experienced IT Systems Analyst to join our UK team at Granta Park near Cambridge. This position will report to our Associate Director, IT Operations & Cyber Security and will be instrumental in supporting and advancing the IT systems throughout the organisation.

Your mission will be to ensure the reliability, security, and efficiency of our IT infrastructure, from user endpoints to our core server environment. You will be a key driver in maintaining our high standards of IT service, strengthening our cybersecurity posture, and delivering robust solutions that empower our scientific and operational teams across the UK and US.

Your responsibilities include (but not limited to):

• Frontline & Escalation Support : Act as a primary point of contact for IT support for UK colleagues and provide expert remote support globally, managing the helpdesk to ensure timely resolution of 1st and 2nd line tickets and appropriate escalation to maintain user satisfaction.
• User & Systems Administration : Manage the full employee IT lifecycle, including hardware/software setup for new joiners and secure off-boarding. Administer and troubleshoot critical server environments (Windows/Linux), virtualisation platforms (Hyper-V), and networking equipment to maintain a 99.9% uptime.
• Security & Operational Excellence : Collaborate with IT leadership to advance our cybersecurity posture by implementing and managing security tools (e.g., Darktrace, Mimecast), supporting enterprise security and disaster recovery drills, and diligently documenting all systems and processes to create a robust knowledge base.
• Continuous Improvement & Project Delivery : Proactively identify opportunities to streamline, upgrade, and integrate IT systems. Lead and contribute to IT project work, from scoping to delivery, ensuring solutions are implemented on time and within budget to meet corporate goals and empower scientific R&D.

Qualifications

Skills, experience and competencies

Knowledge

• Core Expertise:  You apply strong expertise in IT systems administration to independently manage work, connecting your technical knowledge of platforms like Microsoft 365 administration (Office 365, SharePoint, Teams), Active Directory, and Azure AD / Entra ID (including Single Sign-On / SSO).
  • Some experience with Linux/Unix systems and administration, alongside PowerShell scripting skills will be helpful.
  • Experience with help desk / ticket systems and diligent documentation practices is key.
• Data / Insight:  You design and execute analyses of system performance and security data, integrating multiple sources (e.g., monitoring tools, helpdesk metrics) to generate actionable insights and recommend practical improvements to our IT environment.
  •  A security-focused mindset with experience working with modern security vendors, operations, and enterprise-grade security platforms
• Influence & Collaboration:  You interpret and communicate technical information to diverse scientific and operational teams, building relationships across the organization to influence discussions, promote IT best practices, and achieve project goals.

Job Complexity

• Task / Project Delivery:  You work independently on IT projects of moderate scope, such as system upgrades or new platform rollouts, requiring analysis of technical requirements, user impact, and established practices to contribute effectively to team and project objectives.
• Problem-Solving:  You analyze and resolve IT problems by evaluating system logs, user-reported issues, and relevant precedents. You are adept at adapting existing methods to develop effective solutions within our established security and operational policies.
• Strategic Impact:  Your decisions may directly influence the execution of IT projects and affect departmental outcomes. You contribute to the planning and delivery of work that is aligned with our operational goals and cybersecurity strategy.

Independence

• Autonomy:  You operate with moderate autonomy under established policies and management guidance, taking ownership of your projects and responsibilities with work being reviewed at key milestones.
• Decision-Making:  You make decisions that affect project execution and team outcomes, applying sound judgment within established processes to manage work priorities and operational plans.

Values & Behaviours

• One Team:  You act as a role model for teamwork, building collaborative relationships across departments and coaching colleagues to create an inclusive and supportive environment.
• Adventurous:  You introduce new ways of working and technologies to the team, encouraging calculated risk-taking and experimentation to improve performance and efficiency.
• Dedicated to our Mission:  You own the outcomes of your projects, ensuring they are aligned with our organizational priorities and motivating others by connecting your work to Bicycle's scientific purpose.

Desirable Experience

• Industry Experience : Experience in a biotech, biopharma, or life sciences environment.
• Security tools : Experience working with Darktrace, Mimecast, Sophos and Tenable.
• Compliance & Standards : Experience working in regulated environments such as SOX and/or ISO 27001, and awareness of general cybersecurity standards.
• Scientific Computing : Experience with High-Performance Computing (HPC) systems (on-prem/cloud), including GPU technologies.
• Cloud Platforms : Administration experience with cloud platforms such as Azure, AWS, or GCP.
• Enterprise Tools : Experience with Mobile Device Management (MDM) platforms, enterprise-grade backup systems, and long-term data storage solutions.
• Specialised Systems : Familiarity with Veeva systems and experience working under lab conditions.
• Networking : Knowledge of enterprise-grade networking (Firewalls including Palo Alto, SSL/IPSEC VPNs).
• Previous experience of project delivery

Additional Information

• Pension (10% employer contribution)
• Private Medical Insurance (PMI) (including optical and dental cover)
• Health Cash Plan
• Group Life Assurance (4x basic salary)
• Group Income Protection
• Employee Assistance Program (EAP)
• Cycle to Work scheme
• Gym membership (subsidized by Company if on campus, subsidized by PMI if joined elsewhere)
• Time off (28 days annual leave in addition to bank holidays & the option to buy up to 5 additional days annually)
• Competitive reward including annual company bonus
• Employee recognition schemes
• Enhanced parental leave policies
• Flexible working environment
• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.