SRA, Histology

Position Summary:

We are seeking an enthusiastic Senior Research Associate specializing in histopathology to join our Histology team. The candidate will work closely with our team of scientists to advance our somatic genomics platform. The successful candidate will perform pathological assessment and characterization of tissue samples across a range of diseases and support our histology platform through high-quality tissue preparation and workflow management. This role would suit a biomedical scientist with specialty training in histology or a histopathologist looking for a role within a Biotech company.

The ideal candidate will thrive in a fast-paced, cross-functional environment, supporting delivery across prioritized workstreams with agility, positivity, and a proactive mindset. They will demonstrate initiative in solving problems, raising concerns, and driving improvements, while remaining committed to continuous learning, open feedback, and working beyond their comfort zone.

Responsibilities: 

• Perform histopathological assessment and support interpretation of human tissue samples, including but not limited to gastrointestinal, pulmonary, and other disease-relevant tissues to identify disease-relevant tissue regions.
• Assess tissue sample quality and suitability for project use in phenotype-specific isolation workflows
• Identify and annotate disease-relevant tissue regions to support downstream molecular profiling, microdissection, and somatic variant analysis
• Carry out histological techniques including dissection, tissue processing, embedding, sectioning, immunohistochemistry, immunofluorescence and specialized staining protocols.
• Review and support the interpretation of histology, immunohistochemistry (IHC), and tissue-based assay data to enable scientific decision-making
• Collaborate cross-functionally to support process optimization and method development.
• Ensure accurate handling, labelling and traceability of human tissue samples throughout the laboratory workflow
• Maintain compliance with regulatory requirements and quality standards, including the Human Tissue Act and COSHH
• Contribute to continuous improvement initiatives to enhance laboratory efficiency, reproducibility, and turnaround times

Qualifications:

Essential

• BSc or MSc degree in biochemistry, molecular biology, biomedical science or related field
• 3+ years of relevant post-graduation experience
• Experience working within a histopathology lab within either a Biotech, academia or NHS environment
• Specialist training and practical experience in histology techniques and tissue-based assays
• Proficiency in tissue sectioning, H&E staining, immunohistochemistry (IHC), immunofluorescence (IF) and digital pathology workflows.
• Expertise in histological assay development, optimisation, and troubleshooting.
• Ability to work independently while collaborating effectively with multidisciplinary teams
• Knowledge and experience of working under HTA regulations
• Strong communication and collaborative skills with the ability to work effectively in a fast-paced startup environment
• Use of laboratory information management systems (Benchling preferred)

Desirable

• Knowledge of image analysis and digital pathology software
• Experience of working in a high-throughput laboratory environment
• Familiarity with automated histology instrumentation
• Experience in a variety of molecular biology techniques, including nucleic acid extraction and NGS library preparation.
• Experience working with laser capture microdissection

Values and Behaviors:

• Encourage respectful disagreement and cultivate open-minded, ego-free interactions to continuously push each other towards excellence
• Seek out diverse perspectives; practice active listening and genuine curiosity to ensure all contributions are valued, regardless of source
• Recognize the impact of your behavior, language and attitudes, and strive for balanced, meaningful exchanges that enhance mutual growth and understanding in all interactions
• Use a company-first mindset to guide decision-making; prioritize team over individual success
• Take calculated risks and challenge convention in the quest for exceptional outcomes

About Quotient:

Quotient Therapeutics is a privately-held, early stage company developing breakthrough medicines informed by natural somatic genetic diversity present in patients. Through our work in somatic genomics, we are forging a new status quo for biopharma research and development across a broad pipeline of internal and partnered programs. 

The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS).

Quotient Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies:

Quotient Therapeutics (“Quotient”) and Flagship Pioneering (“FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Quotient, FSP or their employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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