VP/SVP, Biology and Translational Science

Company Summary:  

Prologue Medicines uses advances in structural predictions and large language models to functionally annotate the entire viral proteome to leverage millennia of viral evolution for the development of transformative medicines. Prologue has nominated two development candidates and is building a broad pipeline of therapeutics across several therapeutic areas. One of Prologue Medicines’ founding principles is to build an inclusive and exciting working environment that fosters personal and professional growth by ensuring that all team members contribute to and feel ownership of our scientific vision.  

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at  .  

Position Summary:  

We are seeking an exceptional scientific leader to serve as VP/SVP, Biology & Translational Science, responsible for driving our discovery and early development strategy from target identification through IND and continue to support the program as needed through clinical development. This individual will integrate deep expertise in immunology, translational science and/or protein biologics to build a high-impact pipeline and ensure successful progression of programs into the clinic. The ideal candidate will have a proven ability to develop effective strategies and execution plans to advance early molecules through preclinical development to ensure emerging assets exhibit strong differentiation and possibility of success. They should have an excellent understanding of the landscape of immune-mediated diseases to help build a diversified pipeline.. The successful candidate will be an enthusiastic, goal-driven individual who participates as a strategic leader while fostering a culture of executional excellence.   

Key Responsibilities:  

Translational Science & Clinical Readiness  

• Define translational strategies to bridge preclinical findings to human studies
• Lead identification and implementation of biomarkers (PD, predictive, and safety)
• Ensure programs are designed with clinical endpoints and patient stratification in mind
• Increase probability of clinical success through mechanism-based approaches.
• In collaboration with PKPD/ QSP modeling team, develop translational frameworks for AI enabled derisking of drug development path  

Biologics Development (Hit ID to IND) 

• Lead progression of protein biologics programs from hit identification through lead optimization and IND-enabling studies
• Partner cross-functionally with discovery and development teams to build out and drive comprehensive IND strategy, including pharmacology, safety, and translational packages
• Ensure clear go/no-go decision frameworks across discovery and preclinical stages
• Proactively recognize and develop creative solutions for emerging technical and scientific issues  

Discovery Biology & Target Strategy  

• Lead target identification, evaluation, and nomination grounded in human biology and disease relevance
• Define and drive biological hypotheses aligned with company strategy, with a focus on immunology
• Oversee development of robust in vitro and  in vivo models to validate targets and mechanisms
• Build and prioritize a portfolio strategy for multiple differentiated biologics programs  

Leadership & Cross-Functional Integration  

• Build, mentor and lead high-performing teams delivering across biology, pharmacology, and translational science. Identify, initiate, and manage productive collaborations with CROs, partners and academic labs as appropriate to driving projects forward and collaborate closely with clinical development, regulatory, and executive leadership
• Develop, motivate and inspire a high-performing Biology and Translational Science organization
• Serve as an enterprise leader, driving cross-functional alignment, clear decision-making, and a culture of accountability, innovation, and executional excellence.
• Serve as a key scientific voice with board members, investors, and external partners
• Foster a culture of rigor, innovation, collaborative and decisive execution  

Qualifications:  

• PhD or MD/PhD in pharmacology or biological disciplines such as immunology, cellular biology, oncology, or biochemistry, with 10+ years direct pharmaceutical experience beyond postdoctoral work 
• Deep expertise in immunology with a strong understanding of disease biology
• Proven track record advancing protein biologics from hit identification to IND
• Significant experience in target selection and nomination
• Demonstrated ability to lead cross-functional teams to drive go/no go decisions
• Excellent project management skills and the ability to effectively manage CROs and to facilitate interactions with academic labs and companies to ensure project progression.
• Demonstrated success in translational science, including biomarker strategy and IND-enabling work and direct experience in supporting IND strategy and documentation, including writing relevant pharmacology sections of INDs.
• Flexibility to dynamical adapt workplans and lead teams through changing priorities and deadlines.
• A pioneering mindset to grow a startup venture
• Prior experience working in smaller companies is highly preferred  

Leadership Profile  

• Strategic thinker with strong scientific judgment
• Ability to make high-quality decisions under uncertainty
• Skilled at balancing innovation with execution discipline
• Effective communicator with strong external presence
• Passion for building teams and developing talent  

Impact  

This role will shape the company’s scientific direction and pipeline, directly influencing the success of programs entering the clinic and ultimately improving patient outcomes.  

Flagship Pioneering and our ecosystem companies are  committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.  

Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $275,000 - $350,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Prologue Medicines, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Prologue Medicines, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

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